Distribution of the cellular inflammatory pattern in induced sputum in an eosinophilic severe asthma population

<b>Introduction:</b> There are several studies that evaluate the cellular pattern in severe asthma, but not in a subgroup of severe eosinophilic asthma <b>Objective:</b> To evaluate the sputum inflammatory cellular pattern in severe eosinophilic asthma <b>Methods:</b> We have evaluated 80 patients with severe eosinophilic asthma from the Asthma Unit of our hospital. They were patients with peripheral eosinophilia&gt; 220. Subsequently, a group with eos&gt; 300 was selected. Induced sputum was performed, of which 68 were viable. In these patients, the inflammatory cell pattern of the sputum was analyzed and we divided the sample into neutrophilic patients (N&gt;61%, e &lt;2%), eosinophilic (e&gt;2%; N&lt;61%), mixed (eos&gt;2%, N&gt;61%) and paucigranulocytic (eos &lt;2%, N &lt;61%). Clinical aspects of allergenic sensitization, pulmonary function and inflammatory in serum, sputum and FeNO were evaluated. <b>Results:</b> (See Table 1 for population with eos &gt;220) Population selected with eos &gt;300 present different age, duration of asthma (years), asthma control, allergic sensizitation and TH2 cells depends on cellular inflammatory pattern in induced sputum. <b>Conclusions:</b> We observed low % eosinophilia sputum in patients with severe bronchoscopic eosinophilic asthma. Our patients with severe eosinophilic bronchial asthma showed different inflammatory patterns in sputum that could explain different clinical behaviors and therapeutic responses.