Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis
Abhijeet Dhiman, Chanchal Kumar, Subodh Kumar Mishra, Kriti Sikri, Ishara Datta, Pradeep Pant, T.P. Singh, Sagarika Haldar, et al. (14 authors)
Molecular Therapy — Nucleic Acids · 2019-10
Abstract
) of 230 nM. This aptamer blocked mycobacterial entry into host cells by binding to surface-associated MS. In addition, we have also demonstrated its application in the detection of tuberculous meningitis (TBM) in patients with sensitivity and specificity each of >97%.
MeSH terms
- Aptamer
- Systematic evolution of ligands by exponential enrichment
- Mycobacterium tuberculosis
- In silico
- G-quadruplex
- Malate synthase
- Virtual screening
- Mycobacterium
- Biology
- DNA
- Chemistry
- Drug discovery
- Tuberculosis
- Enzyme
- Biochemistry
- RNA