Adaptation of Mycobacterium tuberculosis to Biofilm Growth Is Genetically Linked to Drug Tolerance
Jacob P. Richards, Wenlong Cai, Nicholas A. Zill, Wenjun Zhang, Anil K. Ojha
Antimicrobial Agents and Chemotherapy · 2019-09
Abstract
Mycobacterium tuberculosis spontaneously grows at the air-medium interface, forming pellicle biofilms, which harbor more drug-tolerant persisters than planktonic cultures. The underlying basis for increased persisters in M. tuberculosis biofilms is unknown.
MeSH terms
- Biofilm
- Multidrug tolerance
- Mycobacterium tuberculosis
- Biology
- Microbiology
- Tuberculosis
- Population
- Antibiotics
- Mycobacterium smegmatis