Antimicrobial Effects of ZnPc Delivered into Liposomes on Multidrug Resistant (MDR)‐ <i>Mycobacterium tuberculosis</i>

Abstract Tuberculosis is one of the most important global health problems. Multidrug resistant (MDR)‐tuberculosis is caused by Mycobacterium tuberculosis ( M. tuberculosis ) resistant to the first line drugs (rifampin‐isoniazid). Photodynamic antimicrobial chemotherapy (PACT) has reemerged as an alternative against resistant bacteria. In this work, we synthetized liposomes of Dipalmitoylphosphatidylcholine and Cholesterol as carrier of ZnPc. The ZnPc‐liposomes photodynamic activity was tested in two strains of M. tuberculosis , a sensible (ATCC 27294) and MDR‐ M. tuberculosis . As result, both strains were inactivated by ZnPc‐liposomes. The photodynamic activity was dependent of incubation time and light dose supplied. The photokilling activity was considerably higher for sensible strain than for MDR one.