The TetR Family Transcription Factor MAB_2299c Regulates the Expression of Two Distinct MmpS-MmpL Efflux Pumps Involved in Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus
Ana Victoria Gutiérrez, Matthias Richard, Françoise Roquet‐Banères, Albertus Viljoen, Laurent Kremer
Antimicrobial Agents and Chemotherapy · 2019-07
Abstract
Mycobacterium abscessus is a human pathogen responsible for severe respiratory infections, particularly in patients with underlying lung disorders. Notorious for being highly resistant to most antimicrobials, new therapeutic approaches are needed to successfully treat M. abscessus -infected patients. Clofazimine (CFZ) and bedaquiline (BDQ) are two antibiotics used for the treatment of multidrug-resistant tuberculosis and are considered alternatives for the treatment of M. abscessus pulmonary disease.
MeSH terms
- Clofazimine
- Bedaquiline
- Mycobacterium abscessus
- Efflux
- TetR
- Microbiology
- Antibiotics
- Mycobacterium tuberculosis
- Medicine
- Tuberculosis
- Immunology
- Biology
- Mycobacterium