Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4
Lisanne M. van Leeuwen, Pauline Versteegen, Stefan-Dan Zaharie, Sabine van Elsland, A. Jordaan, Elizabeth M. Streicher, Robin M. Warren, Martijn van der Kuip, et al. (9 authors)
Journal of Clinical Microbiology · 2019-06
Abstract
Tuberculous meningitis (TBM), the most severe extrapulmonary manifestation of tuberculosis, is caused by the pathogen Mycobacterium tuberculosis . The M. tuberculosis complex includes seven lineages, all described to harbor a unique geographical dissemination pattern and clinical presentation. In this study, we set out to determine whether a certain M. tuberculosis lineage demonstrated tropism to cause TBM in patients from Cape Town, South Africa.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- Lineage (genetic)
- Biology
- Genotyping
- Sanger sequencing
- Mycobacterium tuberculosis complex
- Genotype
- Virology
- Immunology