Genomic determinants of speciation and spread of the <i>Mycobacterium tuberculosis</i> complex
Álvaro Chiner‐Oms, Leonor Sánchez-Busó, Jukka Corander, Sébastien Gagneux, Simon R. Harris, D B Young, Fernando Gónzález‐Candelas, Iñaki Comas
Science Advances · 2019-06
Abstract
mutations have been under selection during the early spread of human tuberculosis, during later expansions, and in ongoing transmission events. Our results show that linking pathogen evolution across evolutionary and epidemiological time scales points to past and present virulence determinants.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- Biology
- Selection (genetic algorithm)
- Computational biology
- Genetic algorithm
- Genetics
- Molecular epidemiology
- Pathogenesis
- Evolutionary biology
- Virology