Synthesis and antitubercular activity of new <i>N</i> -[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides
Roberto Martı́nez, Gladys J. Nieves Zamudio, Gustavo Pretelin‐Castillo, Rubén O. Torres‐Ochoa, José L. Medina‐Franco, Clara I. Espitia Pinzón, Mayra Silva‐Miranda, Eugenio Hernandez‐Fernandez, et al. (9 authors)
Heterocyclic Communications · 2019-01
Abstract
Abstract Nitro-substituted heteroaromatic carboxamides 1a-e were synthesized and tested against three Mycobacterium tuberculosis cell lines. The activities can be explained in terms of the distribution of the electronic density across the nitro-substituted heteroaromatic ring attached to the amide group. 1,3,5-Oxadiazole derivatives 1c-e are candidates for the development of novel antitubercular agents. Ongoing studies are focused on exploring the mechanism by which these compounds inhibit M. tuberculosis cell growth.
MeSH terms
- Chemistry
- Nitro
- Amide
- Ring (chemistry)
- Oxadiazole
- Mycobacterium tuberculosis
- Stereochemistry
- Combinatorial chemistry
- Tuberculosis
- Medicinal chemistry