The Rate of CD4 T Cell Entry into the Lungs during Mycobacterium tuberculosis Infection Is Determined by Partial and Opposing Effects of Multiple Chemokine Receptors
Stella G. Hoft, Michelle A. Sallin, Keith D. Kauffman, Shunsuke Sakai, Vitaly V. Ganusov, Daniel L. Barber
Infection and Immunity · 2019-04
Abstract
The specific chemokine receptors utilized by Th1 cells to migrate into the lung during Mycobacterium tuberculosis infection are unknown. We previously showed in mice that CXCR3 + Th1 cells enter the lung parenchyma and suppress M. tuberculosis growth, while CX3CR1 + KLRG1 + Th1 cells accumulate in the lung vasculature and are nonprotective.
MeSH terms
- CXCR3
- Biology
- Mycobacterium tuberculosis
- Chemokine receptor
- Parenchyma
- Chemokine
- Immunology
- Lung
- Tuberculosis
- Receptor
- CX3CR1
- Mycobacterium
- Microbiology
- Virology