Advancing the Therapeutic Potential of Indoleamides for Tuberculosis
Shichun Lun, Rokeya Tasneen, Tridib Chaira, Jozef Stec, Oluseye K. Onajole, Tian J. Yang, Christopher B. Cooper, Khisi Mdluli, et al. (13 authors)
Antimicrobial Agents and Chemotherapy · 2019-04
Abstract
Indole-2-carboxamide derivatives are inhibitors of MmpL3, the cell wall-associated mycolic acid transporter of Mycobacterium tuberculosis . In the present study, we characterized indoleamide effects on bacterial cell morphology and reevaluated pharmacokinetics and in vivo efficacy using an optimized oral formulation.
MeSH terms
- Tuberculosis
- Medicine
- Mycobacterium tuberculosis
- Anti-Infective Agents
- Intensive care medicine
- Pharmacology
- Virology