Impact of the Polymorphism of the <i>PACRG</i> and <i>CD80</i> Genes on the Development of the Different Stages of Tuberculosis Infection.

BACKGROUND: and METHODS: A total of 357 patients with TB (130 cases with primary TB and 227 cases with secondary TB) from the Siberian region of Russia as well as 445 healthy controls were studied. The study was performed at the Research Institute of Medical Genetics, Tomsk NRMC, Tomsk, Russia, between July 2015 and November 2016. Genotyping was carried out using MALDI-TOF mass spectrometry and PCR-RFLP. The associations between the single-nucleotide polymorphisms and TB were assessed using logistic regression adjusting for covariates (age and gender). Multiple testing was addressed via the experiment-wise permutation approach. The statistical significance threshold was a P value less than 0.05 for the permutation P values. The analyses were done in R 3.2 statistical software. RESULTS: appeared to be both a risk factor for reactivation (secondary TB) and a protector against primary infection. CONCLUSION: genes were associated with susceptibility to different forms of TB infection in the Russian population.