Genetic diversity and drug resistance of <i>Mycobacterium tuberculosis</i> in Ecuador
Jeannete Zurita, N. Espinel, Pedro Barba, David Ortega-Paredes, Camilo Zurita-Salinas, Yndra Cordero de Rojas, Iliana Alcocer
The International Journal of Tuberculosis and Lung Disease · 2019-02
Abstract
BACKGROUND: in Quito, Ecuador is not well known. OBJECTIVE: strains in Ecuador. DESIGN: isolates from 104 patients. Isolates were phenotypically resistant to rifampicin (RMP) and/or isoniazid (INH). The genotype was determined using 24-locus mycobacterial interspersed repetitive units-variable-number tandem repeats (MIRU-VNTR). RESULTS: G: Thr324Ser, Thr314Ala, Ala312Pro, Trp351Stop and deleted G at 296 codon. The Latin American Mediterranean (LAM) (33.7%) and Ghana (30.8%) lineages presented most of the main mutations observed. CONCLUSION: G and indicates that LAM is the most prevalent lineage.
MeSH terms
- rpoB
- INHA
- Mycobacterium tuberculosis
- Genotype
- Genetics
- Genetic diversity
- Isoniazid
- Locus (genetics)
- Biology
- Drug resistance
- Rifampicin
- Tuberculosis
- Variable number tandem repeat
- Start codon
- Gene
- Virology
- Medicine