TB Research

Tuberculosis Treatment Outcomes Among Children in Rural Southern Mozambique: A 12-year Retrospective Study

Moon TD, Nacarapa E, Verdu ME, Macuácua S, Mugabe D, Gong W, Carlucci JG, Ramos JM, et al. (9 authors)

The Pediatric infectious disease journal · 2019-10

Abstract

Background Globally, tuberculosis (TB) remains a serious cause of morbidity and mortality for children. Mozambique is 1 of 30 high TB and TB/HIV burden countries. This study aimed to assess treatment outcomes of childhood TB in Chókwè District, Mozambique. Methods A retrospective cohort study of children Results Nine hundred thirty-three cases of childhood TB were enrolled, 45.9% of which were female and 49.6% were Conclusions Most children in this cohort had favorable TB treatment outcomes. Worse outcomes were observed for younger children and if anti-TB treatment started ≤3 months after initiation of antiretroviral therapy. Rigorous screening for TB and isoniazid preventative therapy may reduce the burden of TB in this population and lead to better outcomes.

MeSH terms

  • Humans
  • Tuberculosis
  • Cross Infection
  • Antitubercular Agents
  • Treatment Outcome
  • Survival Analysis
  • Retrospective Studies
  • Adolescent
  • Child
  • Child, Preschool
  • Infant
  • Infant, Newborn
  • Rural Population
  • Hospitals
  • Mozambique
  • Female
  • Male