Tuberculosis Treatment Outcomes Among Children in Rural Southern Mozambique: A 12-year Retrospective Study
Moon TD, Nacarapa E, Verdu ME, Macuácua S, Mugabe D, Gong W, Carlucci JG, Ramos JM, et al. (9 authors)
The Pediatric infectious disease journal · 2019-10
Abstract
Background Globally, tuberculosis (TB) remains a serious cause of morbidity and mortality for children. Mozambique is 1 of 30 high TB and TB/HIV burden countries. This study aimed to assess treatment outcomes of childhood TB in Chókwè District, Mozambique. Methods A retrospective cohort study of children Results Nine hundred thirty-three cases of childhood TB were enrolled, 45.9% of which were female and 49.6% were Conclusions Most children in this cohort had favorable TB treatment outcomes. Worse outcomes were observed for younger children and if anti-TB treatment started ≤3 months after initiation of antiretroviral therapy. Rigorous screening for TB and isoniazid preventative therapy may reduce the burden of TB in this population and lead to better outcomes.
MeSH terms
- Humans
- Tuberculosis
- Cross Infection
- Antitubercular Agents
- Treatment Outcome
- Survival Analysis
- Retrospective Studies
- Adolescent
- Child
- Child, Preschool
- Infant
- Infant, Newborn
- Rural Population
- Hospitals
- Mozambique
- Female
- Male