Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates
Yee JL, Prongay K, Miles B, Smedley J, Hansen SG, Axthelm MK, Ardeshir A, Van Rompay KKA, et al. (10 authors)
Journal of medical primatology · 2019-05
Abstract
We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.
MeSH terms
- Animals
- Macaca mulatta
- Mycobacterium tuberculosis
- Tuberculosis
- Monkey Diseases
- Enzyme-Linked Immunosorbent Assay
- Interferon-gamma Release Tests