TB Research

Die another way: Ferroptosis drives tuberculosis pathology

Meunier E, Neyrolles O

The Journal of experimental medicine · 2019-02

Abstract

In this issue of JEM , Amaral et al. (https://doi.org/10.1084/jem.20181776) provide the first evidence that ferroptosis, a newly described form of regulated cell death, is detrimental for the host during a Mycobacterium tuberculosis infection. This finding has important implications for the development of host-directed therapies for tuberculosis.

MeSH terms

  • Humans
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Necrosis
  • Cell Death
  • Ferroptosis