Disseminated Nocardia asiatica infection in an immunocompromised individual: A rare entity needs careful vigilance
Banerjee B, Gupta R, Varma M, Mukhopadhyay C, Shaw T
Journal of infection and public health · 2019-01
Abstract
Nocardia asteroides complex and Nocardia brasiliensis are common etiological agents of disseminated nocardiosis among immunocompromised individuals. Here we reported an uncommon case of disseminated nocardiosis with the involvement of lung, brain, soft tissue & pancreas by a rarely isolated species Nocardia asiatica in a HIV infected individual. Diagnosis was initially misinterpreted as tuberculosis based on the clinical and radiological findings. The isolate was identified to the species level with a 16S rRNA gene analysis & in vitro susceptibility was done as resistance is not uncommon among them. Clinical cure & radiological regression of lesions was observed except for brain after treatment with meropenem, amikacin & cotrimoxazole.
MeSH terms
- Humans
- Nocardia
- Nocardia Infections
- HIV Infections
- Amikacin
- DNA, Bacterial
- DNA, Ribosomal
- RNA, Ribosomal, 16S
- Anti-Bacterial Agents
- Treatment Outcome
- Microbial Sensitivity Tests
- Sequence Analysis, DNA
- Immunocompromised Host
- Adult
- Male
- Trimethoprim, Sulfamethoxazole Drug Combination
- Meropenem