Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-resistant Tuberculosis
Purchase SE, Garcia-Prats AJ, De Koker P, Draper HR, Osman M, Seddon JA, Schaaf HS, Hesseling AC
The Pediatric infectious disease journal · 2019-06
Abstract
Levofloxacin is used for the treatment and prevention of multidrug-resistant tuberculosis in children, but current adult formulations are poorly palatable. A questionnaire administered to caregivers of 27 children taking a novel 100 mg dispersible taste-masked levofloxacin tablet found the new formulation to be more palatable (69%) and easier to prepare (81%) than the adult formulation. This formulation may assist children to better adhere to anti-tuberculous therapy.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- Tablets
- Antitubercular Agents
- Drug Compounding
- Child, Preschool
- Infant
- South Africa
- Female
- Male
- Levofloxacin