Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection

In recent years, increasing evidence has suggested that circRNAs can serve as novel diagnostic markers for many diseases. However, little is known about the value of circRNAs in the diagnosis of active tuberculosis (TB). In this study, 10 circRNAs which we previously found to be involved in Mycobacterium tuberculosis infection were selected as candidate targets for subsequent circulating circRNA assay. Compared with healthy controls, plasma levels of hsa_circ_0001204 and hsa_circ_0001747 were significantly decreased ( P P < 0.001). Our present study indicates that circulating hsa_circ_0001204 and hsa_circ_0001747 may represent novel plasma biomarkers for TB diagnosis.