Diagnostic Yield of Xpert MTB/RIF in Bronchoalveolar Lavage in Children with Probable Pulmonary Tuberculosis
Saini I, Mukherjee A, Gautam H, Singla M, Jat KR, Lodha R, Singh UB, Kabra SK
Indian pediatrics · 2018-12
Abstract
Objective To evaluate utility of Xpert MTB/RIF in bronchoalveolar lavage fluid in children with probable pulmonary tuberculosis. Methods Children with probable pulmonary tuberculosis with negative smear and Xpert on induced sputum/gastric aspirate were subjected to bronchoalveolar lavage (BAL) for Xpert assay and mycobacterial liquid culture. Data of children Results Of 41 enrolled children, 24 (58.5%) had Xpert positive in BAL fluid and 11 (26.8%) had culture confirmed tuberculosis (BAL fluid;10; sputum,1). The sensitivity of Xpert in BAL fluid among probable and culture confirmed tuberculosis cases was 58.5% (24/41) and 81.8% (9/11), respectively. Conclusion Xpert in bronchoalveolar lavage fluid has good sensitivity in both probable and confirmed pulmonary tuberculosis in children.
MeSH terms
- Bronchoalveolar Lavage Fluid
- Humans
- Tuberculosis, Pulmonary
- Sensitivity and Specificity
- Bronchoalveolar Lavage
- Adolescent
- Child
- Child, Preschool
- Female
- Male