In Vitro Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis
Serebryakova VA, Urazova OI, Novitsky VV, Vengerovskii AI, Kononova TE
Bulletin of experimental biology and medicine · 2018-11
Abstract
The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNγ in drug-sensitive tuberculosis.
MeSH terms
- Leukocytes, Mononuclear
- Humans
- Mycobacterium bovis
- Mycobacterium tuberculosis
- Tuberculosis, Pulmonary
- Tumor Necrosis Factor-alpha
- Interleukin-2
- Interleukin-12
- BCG Vaccine
- Drug Combinations
- Anti-Bacterial Agents
- Case-Control Studies
- Drug Resistance, Multiple, Bacterial
- Adult
- Middle Aged
- Female
- Male
- Interferon-gamma
- Primary Cell Culture
- Levofloxacin