High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial
Cranmer LM, Draper HR, Mandalakas AM, Kim S, McSherry G, Krezinski E, Coetzee J, Mitchell C, et al. (12 authors)
The Pediatric infectious disease journal · 2018-10
Abstract
Young HIV-exposed children are at high risk for TB infection. We performed QuantiFERON-TB Gold among HIV-exposed children in South Africa at enrolment and 1-year follow-up. The incidence of TB infection was high for HIV+ (11 cases per 100 child-years) and HIV-exposed uninfected children (15 cases per 100 child-years). QuantiFERON-TB Gold may identify HIV-exposed children at risk for TB disease progression.
MeSH terms
- Humans
- Tuberculosis
- HIV Infections
- Isoniazid
- Antitubercular Agents
- Incidence
- Prevalence
- Double-Blind Method
- Child, Preschool
- Infant
- South Africa
- Female
- Male
- Clinical Trials as Topic
- Interferon-gamma
- Latent Tuberculosis