Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia
Chernyaeva E, Rotkevich M, Krasheninnikova K, Yurchenko A, Vyazovaya A, Mokrousov I, Solovieva N, Zhuravlev V, et al. (10 authors)
Emerging infectious diseases · 2018-03
Abstract
Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance.
MeSH terms
- Humans
- Mycobacterium tuberculosis
- Tuberculosis
- Spondylitis
- Antitubercular Agents
- Microbial Sensitivity Tests
- Phylogeny
- Drug Resistance, Bacterial
- Virulence
- Mutation
- Genome, Bacterial
- Geography
- Russia
- Whole Genome Sequencing